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After gastric cancer has been diagnosed, tests are done to find out if cancer cells have spread within the stomach or to other parts of the body. The process used to find out if cancer has spread within the stomach or to other parts of the body is called staging. The information gathered from the staging process determines the stage of the disease. It is important to know the stage in order to plan treatment. The following tests and procedures may be used in the staging process: Endoscopic ultrasound (EUS): A procedure in which an endoscope is inserted into the body, usually through the mouth or rectum. An endoscope is a thin, tube-like instrument with a light and a lens for viewing. A probe at the end of the endoscope is used to bounce high-energy sound waves (ultrasound) off internal tissues or organs and make echoes. The echoes form a picture of body tissues called a sonogram. This procedure is also called endosonography. CT scan (CAT scan): A procedure that makes a series of detailed pictures of areas inside the body, such as the chest, abdomen, or pelvis, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerised tomography, or computerised axial tomography. PET scan (positron emission tomography scan): A procedure to find malignant tumor cells in the body. A small amount of radioactive glucose (sugar) is injected into a vein. The PET scanner rotates around the body and makes a picture of where glucose is being used in the body. Malignant tumor cells show up brighter in the picture because they are more active and take up more glucose than normal cells do. A PET scan and CT scan may be done at the same time. This is called a PET-CT. MRI (magnetic resonance imaging) with gadolinium: A procedure that uses a magnet, radio waves and a computer to make a series of detailed pictures of areas inside the body. A substance called gadolinium is injected into a vein. The gadolinium collects around the cancer cells so they show up brighter in the picture. This procedure is also called nuclear magnetic resonance imaging (NMRI). Laparoscopy: A surgical procedure to look at the organs inside the abdomen to check for signs of disease. Small incisions (cuts) are made in the wall of the abdomen and a laparoscope (a thin, lighted tube) is inserted into one of the incisions. Other instruments may be inserted through the same or other incisions to perform procedures such as removing organs or taking tissue samples to be checked under a microscope for signs of cancer. A solution may be washed over the surface of the organs in the abdomen and then removed to collect cells. These cells are also looked at under a microscope to check for signs of cancer.

Cancer can spread through tissue, the lymph system and the blood: The cancer spreads from where it began by growing through the muscle into nearby areas called direct spread or extension. Lymph system. The cancer spreads from where it began by getting into the lymph system. The cancer travels through the lymph vessels to other parts of the body. The cancer spreads from where it began by getting into the blood. The cancer travels through the blood vessels to other parts of the body. Cancer may spread from where it began to other parts of the body. When cancer spreads to another part of the body, it is called metastasis. Cancer cells break away from where they began (the primary tumor) and travel through the lymph system or blood. Lymph system. The cancer gets into the lymph system, travels through the lymph vessels and forms a tumor (metastatic tumor) in another part of the body. The cancer gets into the blood, travels through the blood vessels and forms a tumor (metastatic tumor) in another part of the body. The metastatic tumor is the same type of cancer as the primary tumor. For example, if gastric cancer spreads to the liver, the cancer cells in the liver are actually gastric cancer cells. The disease is metastatic gastric cancer.

Stage 0 (Carcinoma in Situ) In stage 0, abnormal cells are found in the mucosa (innermost layer) of the stomach wall. These abnormal cells may become cancer and spread into nearby normal tissue. Stage 0 is also called carcinoma in situ. Layers of the stomach wall. The wall of the stomach is made up of the mucosa (innermost layer), submucosa, muscle layer, subserosa and serosa (outermost layer). The stomach is an organ in the upper abdomen. Stage I Stage I is divided into stages IA and IB. Stage IA: Cancer has formed in the mucosa (innermost layer) of the stomach wall and may have spread to the submucosa (layer of tissue next to the mucosa). Stage IB: Cancer: has formed in the mucosa (innermost layer) of the stomach wall and may have spread to the submucosa (layer of tissue next to the mucosa). Cancer has spread to 1 or 2 nearby lymph nodes; or has formed in the mucosa of the stomach wall and has spread to the muscle layer Stage II Stage II gastric cancer is divided into stages IIA and IIB. Stage IIA: Cancer: may have spread to the submucosa (layer of tissue next to the mucosa) of the stomach Cancer has spread to 3 to 6 nearby lymph nodes; or has spread to the muscle layer of the stomach wall. Cancer has spread to 1 or 2 nearby lymph nodes; or has spread to the subserosa (layer of connective tissue next to the muscle layer) of the stomach wall. Stage IIB: Cancer: may have spread to the submucosa (layer of tissue next to the mucosa) of the stomach Cancer has spread to 7 to 15 nearby lymph nodes; or has spread to the muscle layer of the stomach wall. Cancer has spread to 3 to 6 nearby lymph nodes; or has spread to the subserosa (layer of connective tissue next to the muscle layer) of the stomach wall. Cancer has spread to 1 or 2 nearby lymph nodes; or has spread to the serosa (outermost layer) of the stomach wall. Stage III Stage III gastric cancer is divided into stages IIIA, IIIB, and IIIC. Stage IIIA: Cancer has spread: to the muscle layer of the stomach Cancer has spread to 7 to 15 nearby lymph nodes; or to the subserosa (layer of connective tissue next to the muscle layer) of the stomach wall. Cancer has spread to 3 to 6 nearby lymph nodes; or to the serosa (outermost layer) of the stomach wall. Cancer has spread to 1 to 6 nearby lymph nodes; or to nearby organs, such as the spleen, colon, liver, diaphragm, pancreas, abdomen wall, adrenal gland, kidney, small intestine or to the back of the abdomen. Stage IIIB: Cancer: may have spread to the submucosa (layer of tissue next to the mucosa) or to the muscle layer of the stomach Cancer has spread to 16 or more nearby lymph nodes; or has spread to the subserosa (layer of connective tissue next to the muscle layer) or to the serosa (outermost layer) of the stomach wall. Cancer has spread to 7 to 15 nearby lymph nodes; or has spread from the stomach to nearby organs, such as the spleen, colon, liver, diaphragm, pancreas, abdomenwall, adrenal gland, kidney, small intestine or to the back of the abdomen. Cancer has spread to 1 to 6 nearby lymph nodes. Stage IIIC: Cancer has spread: to the subserosa (layer of connective tissue next to the muscle layer) or to the serosa (outermost layer) of the stomach Cancer has spread to 16 or more nearby lymph nodes; or from the stomach into nearby organs, such as the spleen, colon, liver, diaphragm, pancreas, abdomenwall, adrenal gland, kidney, small intestine or to the back of the abdomen. Cancer has spread to 7 or more nearby lymph nodes. Stage IV In stage IV, cancer has spread to other parts of the body, such as the lungs, liver, distant lymph nodes and the tissue that lines the abdomen wall. Gastric cancer can recur (come back) after it has been treated. The cancer may come back in the stomach or in other parts of the body, such as the liver or lymph nodes.

There are different types of treatment for patients with gastric cancer. Different types of treatments are available for patients with gastric cancer. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. Seven types of standard treatment are used: Endoscopic submucosal Dissection Endoscopic mucosal resection is a procedure that uses an endoscope to remove early-stage cancer and precancerous growths from the lining of the digestive tract without surgery. An endoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also include tools to remove growths from the lining of the digestive tract. Surgery Surgery is a common treatment of all stages of gastric cancer. The following types of surgery may be used: Subtotal gastrectomy: Removal of the part of the stomach that contains cancer, nearby lymph nodes and parts of other tissues and organs near the tumor. The spleen may be removed. The spleen is an organ that makes lymphocytes, stores red blood cells and lymphocytes, filters the blood and destroys old blood cells. The spleen is on the left side of the abdomen near the stomach. Total gastrectomy: Removal of the entire stomach, nearby lymph nodes, and parts of the esophagus, small intestine and other tissues near the tumor. The spleen may be removed. The esophagus is connected to the small intestine so the patient can continue to eat and swallow. Proximal gastrectomy: removal of proximal part of stomach Pylorus preserving Gastrectomy: removal of central part of stomach preserving the pyloric sphincter Nowadays, we prefer to perform laparoscopic (keyhole) or robotic surgery. This is better than the traditional open surgery as the scar is much smaller, therefore the patient is granted less pain with earlier recovery. The surgeon is also able to visualise structures better and perform more accurate surgery with less blood loss. If the tumor is blocking the stomach but the cancer cannot be completely removed by standard surgery, the following procedures may be used: Endoluminalstent placement: A procedure to insert a stent (a thin, expandable tube) in order to keep a passage (such as arteries or the esophagus) open. For tumors blocking the passage into or out of the stomach, surgery may be done to place a stent from the esophagus to the stomach or from the stomach to the small intestine to allow the patient to eat normally. Endoluminal laser therapy: A procedure in which an endoscope (a thin, lighted tube) with a laser attached is inserted into the body. A laser is an intense beam of light that can be used as a knife. Gastrojejunostomy: Surgery to remove the part of the stomach with cancer that is blocking the opening into the small intestine. The stomach is connected to the jejunum (a part of the small intestine) to allow food and medicine to pass from the stomach into the small intestine. Chemotherapy Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the cerebrospinal fluid, an organ or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). The way the chemotherapy is given depends on the type and stage of the cancer being treated. Chemotherapy can be given after surgery which is called adjuvant chemotherapy or it can be given before surgery which is called neoadjuvant chemotherapy. A type of regional chemotherapy being studied to treat gastric cancer is intraperitoneal (IP) chemotherapy. In IP chemotherapy, the anticancer drugs are carried directly into the peritoneal cavity (the space that contains the abdominal organs) through a thin tube. Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment used during surgery that is being studied for gastric cancer. After the surgeon has removed as much tumor tissue as possible, warmed chemotherapy is sent directly into the peritoneal cavity. Radiation therapy Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. External radiation therapy uses a machine outside the body to send radiation toward the area of the body with cancer. Chemoradiation Chemoradiation therapy combines chemotherapy and radiation therapy to increase the effects of both. Chemoradiation given after surgery, to lower the risk that the cancer will come back, is called adjuvant therapy. Chemoradiation given before surgery, to shrink the tumor (neoadjuvant therapy), is being studied. Targeted therapy Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific cancer cells. Targeted therapies usually cause less harm to normal cells than chemotherapy or radiation therapy do. Monoclonal antibodies and multikinase inhibitors are types of targeted therapy used in the treatment of gastric cancer. Monoclonal antibody therapy: This type of therapy uses antibodies made in the laboratory from a single type of immune system These antibodies can identify substances on cancer cells or normal substances that may help cancer cells grow. The antibodies attach to the substances and kill the cancer cells, block their growth or keep them from spreading. Monoclonal antibodies are given by infusion. They may be used alone or to carry drugs, toxins or radioactive material directly to cancer cells. Multikinase inhibitors: These are small-molecule drugs that go through the cell membrane and work inside cancer cells to block multiple protein signals that cancer cells need to grow and divide. Some multikinase inhibitors also have angiogenesis inhibitors. Angiogenesis inhibitors stop the growth of new blood vessels that tumors need to grow. Immunotherapy Immunotherapy is a treatment that uses the patient’s immune system to fight cancer. Substances made by the body or made in a laboratory are used to boost, direct, or restore the body’s natural defenses against cancer. This type of cancer treatment is also called biotherapy or biologic therapy. Immune checkpoint inhibitor therapy is a type of immunotherapy. Immune checkpoint inhibitor therapy: PD-1 is a protein on the surface of T cells that helps keep the body’s immune responses in check. When PD-1 attaches to another protein called PDL-1 on a cancer cell, it stops the T cell from killing the cancer cell. PD-1 inhibitors attach to PDL-1 and allow the T cells to kill cancer cells.